10 Best Gaming Mice With Side Buttons for 2026: MMO, FPS, and Productivity Picks

A great gaming mouse with side buttons can speed up skill rotations, shortcuts, and in-game actions without forcing your hand to reach for the keyboard.

From MMO-heavy setups to versatile all-rounders, this roundup focuses on models that balance comfort, button placement, sensor performance, and customization.

Best 10 Gaming Mouse with Side Buttons Picks for 2026

MMO Macro Pick – Redragon M908 Wired MMO RGB Gaming Mouse

If you want a gaming mouse with side buttons for MMO hotkeys, macros, and quick-access commands, the Redragon M908 is built for exactly that job. It combines 18 programmable buttons, 12 MMO side buttons, and adjustable DPI up to 12400, so you can tailor it for both gaming and everyday use.

Best For: MMO players who want lots of remappable buttons and weight adjustment.

Pros:

• 12 programmable side buttons plus 18 total programmable buttons
• Up to 12400 DPI with 5 preset levels and software adjustment
• Includes an 8-piece weight tuning set for feel customization
• RGB lighting can be disabled if you prefer a simpler setup

Cons:

• Wired-only design
• Right-handed shape may not suit left-handed users
• Bulkier MMO layout is better for command access than minimalism

The M908 is a strong fit if your priority is button count and control rather than a lightweight, stripped-down mouse. Its side-button layout and profile support make it especially practical for complex game bindings.

Budget Side-Key Build – AFUNTA C12 Gaming Mouse

The AFUNTA C12 is a practical gaming mouse with side buttons for players who want extra thumb controls without moving to a premium model. It offers 12 buttons total, 6 programmable left-side keys, and adjustable DPI up to an 8000DPI movement speed claim, making it a flexible option for gaming or general PC use.

Best For: Budget buyers who want extra side controls and basic customization.

Pros:

• 6 programmable side buttons for quick thumb access
• 4 DPI levels from 1000 to 4000, with up to 8000DPI speed claim
• Built-in weights let you adjust the mouse feel
• Compatible with a wide range of systems, including Windows, Mac, Android, and some mobile devices

Cons:

• Lower stated maximum DPI than higher-end MMO mice
• Wired design only
• Button layout may feel busy if you only need a few side commands

If you mainly want side buttons and simple tuning options, the C12 covers the basics well. It is less feature-rich than premium MMO mice, but it still gives you the thumb controls and customization many gamers look for.

High-DPI MMO Contender – UtechSmart Venus Pro Wired MMO Gaming Mouse

The UtechSmart Venus Pro is a feature-packed gaming mouse with side buttons for MMO players who want a highly customizable wired option. It offers 12 side buttons, up to 16400 DPI, 5 profiles, and RGB backlighting, so you can map commands and switch setups quickly during play.

Best For: MMO gamers who want a high-DPI mouse with lots of programmable controls.

Pros:

• 12 side buttons positioned for thumb access
• Up to 16400 DPI with on-mouse sensitivity adjustment
• 5 custom profiles with matching RGB color modes
• Includes 8 internal weights for tuning feel

Cons:

• Wired-only connection
• Right-handed shape limits who can use it comfortably
• MMO-style body is larger than a standard ambidextrous mouse

This model stands out if you want lots of side controls plus a very wide DPI range. The profile system and weight tuning make it easy to adapt the mouse to different games or tasks.

Wireless Long-Life Choice – Razer Naga V2 HyperSpeed Wireless MMO Gaming Mouse

If you want a wireless gaming mouse with side buttons and long battery life, the Razer Naga V2 HyperSpeed is built around flexibility and control. It includes 19 programmable buttons, HyperSpeed wireless and Bluetooth connectivity, and up to 400 hours of battery life on Bluetooth, making it a strong pick for players who want fewer cable constraints.

Best For: Wireless MMO players who want many programmable buttons and long battery life.

Pros:

• 19 programmable buttons for extensive remapping
• Wireless and Bluetooth connectivity for flexible use
• Up to 400 hours of battery life on Bluetooth
• Focus Pro 30K optical sensor and mechanical switches rated for up to 60 million clicks

Cons:

• Uses AA battery power instead of a built-in rechargeable battery
• Premium MMO layout may be more than some users need
• Best features are geared toward Windows users

The Naga V2 HyperSpeed is the most wireless-friendly option in this group and the most advanced overall. If your priority is cutting the cord without giving up button density, it offers a compelling balance of convenience and performance.

MMO Control Pick – Redragon M811 Wired RGB MMO Gaming Mouse

If you want a gaming mouse with side buttons built for lots of remaps, the Redragon M811 puts function first. It offers 15 programmable buttons, including 8 MMO side buttons, plus adjustable DPI so you can tailor it for games or general PC work.

Best For: MMO players and productivity users who want a wired mouse with many side buttons and broad button remapping.

Pros:

• 15 programmable buttons for hotkeys, media controls, and custom binds.
• Default 2 + 8 side-button layout aimed at MMO-style input.
• 5 DPI levels with software support for broader DPI adjustment.
• Ergonomic right-handed shape designed for longer sessions.

Cons:

• Maximum listed sensitivity is 6200 DPI in the details, which is lower than the software-adjustable range mentioned in the description.
• Wired-only design may not suit buyers who want a wireless mouse.
• Large button count may feel excessive if you only need a few extra side buttons.

Overall, the M811 is a practical pick if your priority is maximizing side-button access and custom bindings. It is especially appealing for MMO layouts, but its strength is really in versatility rather than simplicity.

Premium All-Rounder – Logitech G502 Hero Wired Gaming Mouse

The Logitech G502 Hero is a strong gaming mouse with side buttons if you want a more balanced feature set instead of an MMO-heavy layout. It combines 11 programmable buttons, a highly sensitive HERO sensor, and adjustable weights for users who care about precision and feel.

Best For: Players who want a highly configurable wired gaming mouse with side buttons, precise tracking, and adjustable weight.

Pros:

• 11 programmable buttons for customizable gameplay inputs.
• HERO sensor delivers tracking up to 25,600 DPI.
• Adjustable weight system lets you tune balance to your preference.
• LIGHTSYNC RGB adds customizable lighting support.

Cons:

• Only one dedicated side-button count is not specified, so it may not suit MMO users wanting lots of thumb keys.
• Wired design may be a drawback for wireless-minded buyers.
• Features may be more than needed if you only want basic side-button functionality.

In practical use, the G502 Hero stands out as a flexible performance mouse rather than a niche MMO tool. It is a good fit if you want precision, customization, and side buttons without going all-in on a huge button cluster.

Macro Heavy Pick – Redragon M901K MMO Gaming Mouse

If you need a gaming mouse with side buttons for complex macros, the Redragon M901K is built around that idea. It includes 19 programmable buttons, 12 side buttons, and weight tuning, making it a strong option for MMO or MOBA setups that rely on lots of direct inputs.

Best For: MMO and MOBA players who want maximum side-button access, macro remapping, and adjustable mouse weight.

Pros:

• 19 programmable buttons with macro editing support.
• 12 remappable side buttons for keyboard-combo shortcuts.
• Up to eight removable weights for personalized balance.
• Adjustable DPI up to 12,400 with multiple polling-rate settings.

Cons:

• Large button layout may feel crowded for users who prefer a simpler mouse.
• Wired-only design limits desk placement flexibility.
• Feature set is focused more on MMO-style control than lightweight FPS simplicity.

The M901K is the most button-rich option here, so it makes sense if your priority is fast access to many commands. For users who want side buttons and macro depth above all else, it is the most specialized pick in this group.

Ergonomic Precision Pick – Razer Basilisk V3 Customizable RGB Wired Gaming Mouse

If you want a gaming mouse with side buttons that still feels comfortable for long sessions, the Razer Basilisk V3 is built around an ergonomic right-handed shape with a thumb rest and 11 programmable buttons. It also adds a hyperscroll tilt wheel, a 26K DPI optical sensor, and fast optical switches for players who want speed and control in one wired design.

Best For: Right-handed gamers who want an ergonomic wired mouse with plenty of programmable buttons.

Pros:

• 11 programmable buttons for macros, push-to-talk, ping, and other in-game actions
• Ergonomic design with thumb rest for comfortable hand support
• Focus+ 26K DPI optical sensor for precise tracking
• HyperScroll tilt wheel offers free-spin or tactile scrolling modes

Cons:

• Wired USB connection only
• Right-hand orientation may not suit left-handed players

Overall, this is a strong pick if you want a feature-rich gaming mouse with side buttons and a more refined shape than basic MMO-style designs. It balances programmability, accuracy, and comfort without going overboard on complexity.

MMO Button Loadout – Redragon M921 Wired RGB MMO Gaming Mouse

For gamers who want a gaming mouse with side buttons for fast keybind access, the Redragon M921 goes big with 12 side buttons and 18 programmable buttons total. It is designed for MMO-style play, and its adjustable DPI steps, weight-tuning set, and PAW3327 sensor make it a flexible wired option for players who like lots of control at hand.

Best For: MMO and action players who want a high-button-count wired mouse with remapping options.

Pros:

• 12 side buttons and 18 programmable buttons total
• 5 DPI levels, with sensitivity adjustable up to 12,400 DPI
• Includes an 8-piece weight tuning set for a more customized feel
• PAW3327 sensor with up to 1,000 Hz polling rate

Cons:

• Wired-only design
• Aggressive MMO layout may feel busy for simple gaming needs

This mouse makes sense if your game benefits from a lot of dedicated inputs and you want your side buttons easy to reach. It is less about minimalism and more about giving you as many programmable controls as possible.

Tri-Mode Side-Button Flex – SOLAKAKA SM809 Pro MMO Gaming Mouse

If you want a gaming mouse with side buttons that can move between devices easily, the SOLAKAKA SM809 Pro stands out with tri-mode connectivity, 9 side buttons, and 16 programmable controls. Its 24,000 DPI sensor, onboard memory, and swapable magnetic side plates make it a practical choice for players who want flexibility across desktop, laptop, and tablet setups.

Best For: Multi-device gamers who want wireless flexibility and configurable side buttons.

Pros:

• Tri-mode connection with 2.4GHz wireless, Bluetooth 5.0, and USB-C wired
• 9 side buttons and 16 programmable buttons for macros and remapping
• PAW3311 sensor with up to 24,000 DPI
• Onboard memory and web-based configuration for easy profile management

Cons:

• Battery-powered design adds charging or battery maintenance
• Side-button layout may depend on the magnetic plate you choose

This is a strong option if you want more than a basic wired mouse and need side-button flexibility across multiple devices. The removable side plates and wireless modes make it especially useful for mixed gaming and productivity setups.

How We Picked the Best Gaming Mouse with Side Buttons

We focused on side-button layout, comfort over long sessions, sensor quality, software customization, wired versus wireless flexibility, and value. A good Gaming Mouse with Side Buttons should make repeated actions easier, not add clutter or accidental clicks.

Quick Comparison

MMO-focused mice usually offer the most side buttons and macro support, while all-purpose gaming mice tend to keep a smaller, easier-to-learn layout. If you want maximum inputs, prioritize models with many programmable buttons. If you play mixed genres, choose a mouse with a simpler side panel and a more universal shape.

Key Buying Factors for a Gaming Mouse with Side Buttons

Button Count and Placement

More buttons are not always better. Look for a layout you can reach reliably with your thumb, especially if you play fast-paced games. A large cluster can be excellent for MMO or productivity macros, but it may be overkill for FPS play.

Sensor Performance and DPI

Higher DPI numbers are less important than a sensor that tracks smoothly and consistently. Aim for a mouse that feels stable at your preferred sensitivity and offers on-the-fly adjustment if you swap between games.

Shape, Grip, and Weight

The best shape depends on your grip style. Palm grips often benefit from fuller ergonomic shells, while claw and fingertip players may prefer lighter, more agile designs. Adjustable weights can help if you want a heavier feel for control.

Wired Vs. Wireless

Wired mice typically offer simpler setup and no battery concerns. Wireless options are worth considering if you want a cleaner desk and freedom of movement, especially for long sessions where cable drag becomes annoying.

Software and Macro Support

For many buyers, software is the deciding factor. Make sure button remapping, profiles, and macros are easy to configure and save. That matters more than flashy RGB lighting.

Who Should Buy Which Gaming Mouse with Side Buttons?

Choose an MMO-style model if you want the most side buttons for spells, hotkeys, or workflow shortcuts. Pick a more versatile ergonomic mouse if you play a mix of genres and want a familiar shape with extra controls. If wireless convenience matters most, look for a premium option with strong battery life and dependable connection stability. For budget shoppers, a simpler wired mouse can still deliver the side-button speed boost you want without overspending.